Meliora, by her own admission, was born sometime in the mid 9th century, in what is now called Patras, Greece. She became a ghoul to a Gangrel by the name of Olaf in her late 20's, jumping at the chance to put her keen mind to use and to travel the known world. For the next hundred-fifty odd years, she traveled with him and his coterie, functioning as a translator and daytime operative, learning to read and write in six languages. In her free time, the Ventrue companion of Olaf, Desmond Aldred, tutored her in the intricacies of Kindred politics and etiquette; Meliora proved an exceptional student and in many ways knew more about Kindred society than most neonates. It was this knowledge that eventually led to her embrace into Clan Tremere.
During the waning daylight hours in the early 1040's, on an errand for Olaf to protect and guide his wife Sonne, Meliora was attacked by a cadre of Tremere ghouls. They had mistaken her for Olaf's former ghoul, Una, an oracle. Upon realizing their mistake, the leaders of House and Clan decided to keep Meliora for her knowledge of the Kindred - knowledge they desperately needed in those first years they walked the Long Nights.
Meliora was eventually embraced in the winter between 1081 and 1082 by Saharat, at the behest of Therimna, their master. Meliora excelled as a Tremere, applying that keen mind to the study of thaumaturgy and ritual work. Slowly, she moved up the ranks, travelling for House and Clan across Europe, and eventually, creating childer of her own.
In 1830, Meliora was sent to the United States, to prepare to travel to the newest state, California, in 1850. Once there, she joined the fledgling court in San Francisco, and with few exceptions, she has not left the city since.